Genetic testing is a process of checking embryos generated through IVF or ICSI for any chromosomal abnormalities before implantation into the uterus. There are two types of genetic testing: Preimplantation Genetic Testing for Aneuploidies (PGT-A) and Preimplantation Genetic Testing for Monogenic Diseases (PGT-M)
The process is much the same for both PGS and PGD. The difference is that PGS detects chromosomal abnormalities, while PGD detects gene disorders that the embryos might inherit from the parents. For this reason, before starting the procedure, a workup has to be done by testing the parents and looking for the exact mutation in order to create probes that will detect the affected embryos. Both tests begin with the regular IVF treatment procedure – the woman’s cycle is monitored, eggs are harvested and placed in a petri dish with the father’s sperm to fertilise.
Just as with a regular IVF treatment, once fertilised the embryos are left for two to three days to mature. Then, at the point at which they would usually be transferred to the womb, an embryologist takes one or two cells from each embryo with a technique called biopsy. The cells are then sent to a genetic laboratory for analysis.
The appropriate number of embryos not containing abnormalities can then be transplanted to the womb in the hope of achieving pregnancy
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Any couple may choose to undergo PGS, although it is particularly suited to those couples where the woman is aged 35 or older, who have suffered several miscarriages or failed IVF treatments, or who have a family history of chromosomal abnormalities. It is estimated that more than 50% of human eggs have chromosome problems and this is known to be a major cause of miscarriage.
PGD is specifically designed for those couples who have a family history of a serious genetic condition – particularly where it is known to be carried on both sides; for instance if you already have a child with the condition or have had to terminate previous pregnancies because of the condition.
No one takes the decision to undergo genetic screening lightly and we understand that it can be a very painful choice to make. If you do decide to go ahead with genetic screening as part of your IVF or ICSI treatment with us, we will try to make the whole process as smooth as possible, offering impartial advice and emotional support, alongside the practicalities of treatment and testing. Give our clinic a call to book a consultation and find out more about PGS and PGD cost in Dubai.
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